Natural Moisturizing Factor (NMF): Essential for Skin Hydration and Barrier Health
In the context of the stratum corneum, "NMF" stands for Natural Moisturizing Factor. The Natural Moisturizing Factor refers to a mixture of compounds found in the stratum corneum, which is the outermost layer of the epidermis (the skin). NMF plays a critical role in maintaining the hydration and barrier function of the skin.
The Natural Moisturizing Factor is primarily composed of water-binding substances, such as amino acids (e.g., serine, histidine), urea, pyrrolidone carboxylic acid (PCA), sugars (e.g., glycerol), and salts (e.g., sodium, potassium). These substances help to attract and retain water in the stratum corneum, ensuring adequate hydration and flexibility of the skin.
NMF components are derived from the breakdown of filaggrin, a protein found in the granular layer of the epidermis. Filaggrin is converted into amino acids, which contribute to the composition of NMF. These natural moisturizing factors are essential for maintaining the skin's natural moisture balance, preventing excessive water loss (transepidermal water loss), and promoting overall skin health.
Various factors, such as environmental conditions, age, and skin disorders, can affect the composition and levels of NMF in the stratum corneum. When the NMF levels are depleted or imbalanced, the skin can become dry, dehydrated, and more susceptible to issues like roughness, sensitivity, and impaired barrier function.
Skincare products often aim to mimic or enhance the role of NMF by including ingredients that can help attract and retain moisture in the skin, promoting hydration and skin health.
K. M. Adkar RioMax Institute